May 2019 – Bisphosphonate Therapy

Impact of Bisphosphonate Therapy on Dental Implant Outcomes

Mendes V, Dos Santos GO, et al.
Int J Oral Maxillofac Surg. 2019 Mar;48(3):373-381

The purpose of this overview was to assess the methods, quality, and outcomes of systematic reviews conducted to evaluate the impact of bisphosphonates on dental implants and the risk of developing bisphosphonate-related osteonecrosis of the jaw after dental implant surgery. An electronic search without date or language restriction was performed in the PubMed/MEDLINE, Cochrane CENTRAL, Web of Science, and LILACS databases (to January 2018). Eligibility criteria included systematic reviews that evaluated the impact of bisphosphonates on implant outcomes. The quality assessment of the included reviews was done using recognized guidelines.  The search and selection process yielded seven reviews, published between 2009 and 2017.  

The authors believe that the scientific evidence available demonstrates that patients with a history of bisphosphonate use do not present a higher risk of dental implant failure or marginal bone loss compared to patients who have not used bisphosphonates. The literature also suggests that patients who undergo surgical trauma during the installation of dental implants may be more susceptible to bisphosphonate-related osteonecrosis of the jaw.

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